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| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₃₁H₄₃N₃O₈ | 75747-14-7 |
| Description | |
|---|---|
| Overview | A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression. |
| Catalogue Number | 100068 |
| Brand Family | Calbiochem® |
| Synonyms | NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin |
| Product Information | |
|---|---|
| CAS number | 75747-14-7 |
| ATP Competitive | N |
| Form | Purple solid |
| Hill Formula | C₃₁H₄₃N₃O₈ |
| Chemical formula | C₃₁H₄₃N₃O₈ |
| Reversible | N |
| Structure formula Image | |
| Applications |
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| Biological Information | |
|---|---|
| Primary Target | Hsp90 |
| Primary Target IC<sub>50</sub> | EC50 = 7.2 µM for Hsp90 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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