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| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₁₅H₁₀BrN₃O | 676596-65-9 |
| Description | |
|---|---|
| Overview | A Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available. |
| Catalogue Number | 191501 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413. |
| Product Information | |
|---|---|
| CAS number | 676596-65-9 |
| Form | Liquid |
| Formulation | A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO. |
| Hill Formula | C₁₅H₁₀BrN₃O |
| Chemical formula | C₁₅H₁₀BrN₃O |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | GSK-3β |
| Primary Target IC<sub>50</sub> | 18 nM for GSK-3&beta |
| Purity | ≥94% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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