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Bongkrekic Acid, Triammonium Salt

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号:203671-500UG

牌:Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula CAS #
C₂₈H₃₅O₇ · 3NH₄ 1177154-51-6
Description
Overview Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
Catalogue Number 203671
Brand Family Calbiochem®
Synonyms 3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
References
References Hirsch, T., et al. 1998. J. Immunol. 161, 35.
Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
Product Information
CAS number 1177154-51-6
ATP Competitive N
Form Beige-pink solid
Hill Formula C₂₈H₃₅O₇ · 3NH₄
Chemical formula C₂₈H₃₅O₇ · 3NH₄
Reversible N
Structure formula Image Structure formula Image
Applications
Application Bongkrekic Acid, Triammonium Salt, CAS 1177154-51-6, acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore).
Biological Information
Primary Target Mitochondrial mega channel
Purity ≥92% by HPLC
Physicochemical Information
Cell permeable N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase R: 20/21/22-40

Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S Phrase S: 36-22

Wear suitable protective clothing.
Do not breathe dust.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

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