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Bisindolylmaleimide V

市场价：: 0.00

促销价：: ¥0.00

货号：203303-250UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₂₁H₁₅N₃O₂	113963-68-1

Description
Overview	A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70^s6k/p85^s6k in vivo (IC₅₀ 8 µM).
Catalogue Number	203303
Brand Family	Calbiochem®
Synonyms	2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045

References
References	Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6. Davis, P.D., et al. 1992. J. Med. Chem. 35, 177. Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Product Information
CAS number	113963-68-1
ATP Competitive	N
Form	Redish orange solid
Hill Formula	C₂₁H₁₅N₃O₂
Chemical formula	C₂₁H₁₅N₃O₂
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	Negative control compound for protein kinase C inhibition
Primary Target IC<sub>50</sub>	>100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

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Supplemental Information

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