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| Replacement Information |
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| Empirical Formula | CAS # |
|---|---|
| C₂₅H₂₄N₄O₂ | 133052-90-1 |
| Description | |
|---|---|
| Overview | A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα-, βI-, βII-, γ-, δ-, and ε- isozymes. Potently inhibits GSK-3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK-3β immunoprecipitates (IC50 = 170 nM). May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203293) in anhydrous DMSO is also available. |
| Catalogue Number | 203290 |
| Brand Family | Calbiochem® |
| Synonyms | 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850, GF 109203X |
| Product Information | |
|---|---|
| CAS number | 133052-90-1 |
| ATP Competitive | Y |
| Form | Deep orange solid |
| Hill Formula | C₂₅H₂₄N₄O₂ |
| Chemical formula | C₂₅H₂₄N₄O₂ |
| Reversible | Y |
| Structure formula Image | |
| Applications | |
|---|---|
| Application | Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC. |
| Physicochemical Information | |
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| Cell permeable | Y |
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