Adenosine 3?,5?-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt

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Adenosine 3?,5?-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt

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货号：116815-10UMOL

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH	71774-13-5

Description
Overview	A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg.
Overview	Note: 10 µmol = 4.47 mg.
Catalogue Number	116815
Brand Family	Calbiochem®
Synonyms	Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA

References
References	Kawasaki, H., et al. 1998. Science 282, 2275. de Rooij, J., et al. 1998. Nature 396, 474. Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356. Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28. Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336. Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292. Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.

References

Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.

Product Information
CAS number	71774-13-5
ATP Competitive	N
Declaration	Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
Form	Crystalline solid
Hill Formula	C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Chemical formula	C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	cAMP-receptor proteins
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.