Adenosine 3?,5?-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt

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Adenosine 3?,5?-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt

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货号：116814-5UMOL

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH	151837-09-1

Description
Overview	A cell-permeable and reversible inhibitor of protein kinase A (K_i = 11 µM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP.
Overview	Note: 5 µmol = 2.23 mg.
Catalogue Number	116814
Brand Family	Calbiochem®
Synonyms	Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V

References
References	Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356. Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys. 420, 336. Yokozaki, H., et al. 1992. Cancer Res. 52, 2504. Butt, E., et al. 1990. FEBS Lett. 263, 47. Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484. Rothermel, J.D. 1988. Biochem. J. 251, 757. Eckstein, F. 1985. Annu. Rev. Biochem. 54, 367. de Wit, R.J., et al. 1984. Eur. J. Biochem. 142, 255. O'Brian, C.A., et al. 1982. Biochemistry 21, 4371.

References

Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys. 420, 336.
Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
Butt, E., et al. 1990. FEBS Lett. 263, 47.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
Rothermel, J.D. 1988. Biochem. J. 251, 757.
Eckstein, F. 1985. Annu. Rev. Biochem. 54, 367.
de Wit, R.J., et al. 1984. Eur. J. Biochem. 142, 255.
O'Brian, C.A., et al. 1982. Biochemistry 21, 4371.

Product Information
CAS number	151837-09-1
ATP Competitive	N
Form	Crystalline solid
Hill Formula	C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Chemical formula	C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image

Applications

Biological Information
Primary Target	PKA
Primary Target K<sub>i</sub>	11 µM against protein kinase A
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.