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| Replacement Information |
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| Empirical Formula |
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| C₁₈H₁₃N₇ |
| Description | |
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| Overview | A cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control (Cat. No. 328008) and the solid form of this compound (Cat. No. 328007) are also available.. |
| Catalogue Number | 328010 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357. |
| Product Information | |
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| Form | Liquid |
| Formulation | A 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO. |
| Hill Formula | C₁₈H₁₃N₇ |
| Chemical formula | C₁₈H₁₃N₇ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Safety Information | |
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| R Phrase | R: 36/38 Irritating to eyes and skin. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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