Adenophostin A, Hexasodium Salt

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Adenophostin A, Hexasodium Salt

市场价：: 0.00

促销价：: ¥0.00

货号：115500-50UG

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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商品介绍
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Replacement Information

重要规格表

Empirical Formula
C₁₆H₂₀N₅O₁₈P₃ · 6Na

价格及供货情况

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Description
Overview	One of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP₃R; EC₅₀ = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP₃R than IP₃. Stimulates Ca²⁺ release from Ins(1,4,5)P₃-sensitive Ca²⁺ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP₃R (EC₅₀ = 14.7 nM for Ca²⁺ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P₄ binding sites and is resistant to enzymatic degradation.
Catalogue Number	115500
Brand Family	Calbiochem®

References
References	Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206. Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524. DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956. Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683. Marchant, J.S., et al. 1997. Biochemistry 36, 12780. Hirota, J., et al. 1995. FEBS Lett. 368, 248. Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

References

Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206.
Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
Hirota, J., et al. 1995. FEBS Lett. 368, 248.
Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

Product Information
ATP Competitive	N
Form	White solid
Hill Formula	C₁₆H₂₀N₅O₁₈P₃ · 6Na
Chemical formula	C₁₆H₂₀N₅O₁₈P₃ · 6Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image

Applications
Application	Adenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.

Biological Information
Primary Target	Type 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
Primary Target IC<sub>50</sub>	EC50 = 10.9 nM against InsP3R
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.