GSK-3?, Rabbit Skeletal Muscle, Recombinant, E. coli - 炼石商城

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GSK-3?, Rabbit Skeletal Muscle, Recombinant, E. coli

市场价：: 0.00

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货号：361526-5KU

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Overview	Recombinant, rabbit glycogen synthase kinase 3β expressed in E. coli. Dual specificity kinase. One of several protein kinases that phosphorylates glycogen synthase. Other substrates include p90^rsk, Tau, c-Jun, and CREB. Plays a key role in Wnt and insulin signaling.
Overview	Note: 1 KU = 1000 units.
Catalogue Number	361526
Brand Family	Calbiochem®
Synonyms	GSK 3β-Isozyme, Rabbit Skeletal Muscle, Recombinant, E. coli

References
References	Dajani, R., et al. 2001. Cell 105, 721. Wang, Q.M., et al. 1995. Biochem. Biophys. Res. Commun. 208, 796. Fiol, C.J., et al. 1994. J. Biol. Chem. 269, 32187. Wang, Q.M., et al. 1994. J. Biol. Chem. 269, 14566. Wang, Q.M., et al. 1994. Biochemistry 33, 143. deGroot, R.P., et al. 1993. Oncogene 8, 841. Ishiguro, K., et al. 1993. FEBS Lett. 325, 167.

Product Information
Activity	≥250,000 units/ml
Unit of Definition	One unit is defined as the amount of GSK-3 required to catalyze the transfer of 1 pmol phosphate to CREB phosphopeptide KRREILSRRPS(P)YRP (200 µM), in 1 min at 30°C in a reaction volume of 25 µl.
Form	Liquid
Formulation	In 50 mM NaCl, 30 mM Tris-HCl, 5 mM DTT, 1 mM EDTA, 50% glycerol, 0.03% BRIJ^®-35 Detergent, pH 7.5

Applications
Application	GSK-3β, Rabbit Skeletal MuscleHis-Tag®, Human, Recombinant, E. coli, is a dual specificity kinase that plays important roles in insulin- and Wnt-mediated signaling. It is inactivated by phosphorylation at Ser9.

Biological Information

Physicochemical Information
Contaminants	DNase: <10% conversion of RFI DNA to RFII and linear forms. Phosphatases and Proteases: none detected. RNases: <10% RNA degradation.

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Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw aliquot and freeze (-20°C).

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