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GGTI-2147

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号:345885-250UG

牌:Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula CAS #
C₂₈H₃₀N₄O₃ 191102-87-1

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      塑胶安瓿;塑胶针药瓶 250 μg
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      Description
      Overview A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
      Catalogue Number 345885
      Brand Family Calbiochem®
      Synonyms 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
      References
      References Bernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
      Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
      Product Information
      CAS number 191102-87-1
      ATP Competitive N
      Form Off-white solid
      Hill Formula C₂₈H₃₀N₄O₃
      Chemical formula C₂₈H₃₀N₄O₃
      Hygroscopic Hygroscopic
      Reversible N
      Structure formula Image Structure formula Image
      Applications
      Biological Information
      Primary Target GGTase-I
      Primary Target IC<sub>50</sub> 500 nM in blocking the geranyl-geranylation of Rap1A
      Purity ≥95% by HPLC
      Physicochemical Information
      Cell permeable Y
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

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