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| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₂₃H₃₁N₃O₃S | 171744-11-9 |
| Description | |
|---|---|
| Overview | A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC50 = 2 µM vs. 50 µM) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50 = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. |
| Catalogue Number | 345878 |
| Brand Family | Calbiochem® |
| Synonyms | N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA |
| Biological Information | |
|---|---|
| Primary Target | Geranylgeranyltransferase (GGTase) |
| Primary Target IC<sub>50</sub> | 2 µM against GGTase |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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