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Human Recombinant Histone H3.3 K27M

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货号：14-1064

品牌：Millipore 密理博

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Key Applications
ACT
Description
Catalogue Number 14-1064
Trade Name
  • Upstate
Description Human Recombinant Histone H3.3 K27M
Overview Human recombinant histone H3.3 K27M (lysine 27 to methionine mutant) expressed in E Coli. and purified by Fast Protein Liquid Chromatography (FPLC).
Background Information The core histones, H2A, H2B, H3, and H4, form a central octameric structure that binds approximately 147 bp of DNA to form a nucleosome. The nucleosome is the first order of DNA compaction in the nucleus, and is the basic unit of chromatin. The structure of chromatin can be altered by post-translational modifications (PTM) occurring on the C- and N-terminal tails of H2A, H2B, H3, and H4. Histone modifications can either provide or hinder access of key transcriptional complexes to DNA sequences and can regulate the expression of genes. These effects can be deciphered by applications such as chromatin immunoprecipiation (ChIP), which requires high quality chromatin, and essential tools such as histone proteins and appropriate enzymes, to assemble chromatin in vitro. Mutations of lysine 27 (K27) to methionine (M), have been associated with the development of pediatric glioblastoma (see Lewis, P. W. et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 28 Mar 2013).
References
Product Information
Presentation In a buffer containing 20mM sodium phosphate pH 7.0, 1mM EDTA, 0.3 M NaCl, 0.5mM PMSF and 1mM DTT.
Applications
Application Human recombinant histone H3.3 K27M mutant (Lysine to Methionine) expressed in E Coli & purified by Fast Protein Liquid Chromatography (FPLC) & verified mass spectrometry.
Key Applications
  • Activity Assay
Application Notes Suitable for in vitro chromatin assembly and enzyme activity assays
Biological Information
Concentration 1.0 µg/µL
Host E. coli
Purity Greater than 98% purity by SDS PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable at -80ºC for 1 year from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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