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DKK-1, Human Recombinant

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货号：GF170

品牌：Millipore 密理博

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Replacement Information

重要规格表

Source Purity
HEK293 Cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue Number GF170
Description DKK-1 Protein, Human Recombinant
Alternate Names
  • Dickkopf related protein 1
  • DKK1
  • DKK
  • SK
Background Information Dickkopf related protein 1 (Dkk1) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4, and a related protein, Soggy. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
References
Product Information
Presentation Product is filtered through a 0.2 micron filter before lyophilization.
Applications
Application The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.
Biological Information
Purity Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses
Source HEK293 Cells
Cross Reactivity None
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Bioactivity assay: Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at -20°C for up to 6 months from date of receipt.
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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