IGF-1, Human Recombinant

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IGF-1, Human Recombinant

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货号：GF138

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Key Applications	Species	Source	Purity
CULT	Human	E.coli	Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-1.

Description
Catalogue Number	GF138
Replaces	GF006
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Insulin-like Growth Factor-I Protein, Recombinant human
Overview	Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Human IGF-I is a 7.6 kDa protein containing 70 amino acid residues.
Alternate Names	IGF-I
Background Information	Insulin-like Growth Factor (IGF-1) is a polypeptide endocrine hormone similar in structure to insulin. Stimulated by growth hormone and produced primarily in the liver, it binds to the IGF-1 receptor with a high affinity and to the insulin receptor with a much lower affinity. The tyrosine kinase IGF-1 receptor is a potent activator of the Akt signaling pathway, which drives a variety of processes including cell growth and division and apoptosis inhibition. Because approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP), extraction is required to measure extracellular protein concentrations. Increased levels of IGF-1 have been correlated with an increased risk of cancer. In addition, while involved in reducing hemoglobin A1C levels and daily insulin consumption in types 1 and 2 diabetes, these increased levels have been also implicated in the development of diabetic retinopathy. Drugs have been developed as replacement therapy for severe primary IGF-1 deficiency, a group of diseases in which patients do not respond to growth hormone therapy.

References

Product Information
Presentation	Lyophilized from sterile filtered 10 mM Sodium Phosphate, pH 6, containing no additives.

Applications
Application	Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone & cartilage tissue.
Key Applications	Cell Culture
Application Notes	For most in vitro applications, IGF-I exerts its biological activity in the concentration range of 0.2 to 20.0 ng/mL. Responding cells are (partial list): bone, muscle cells, CHO cells. Optimal working dilutions must be determined by end user.

Biological Information
Purity	Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-1.
Source	E.coli
Specific Activity	Human IGF-I is fully biologically active when compared to standards. The ED50 as determined by a cell proliferation assay using FDC-P1 cells is <=10.0 ng/mL corresponding to a specific activity of >=1 x 10e5 units/mg.
Entrez Gene Number	NM_000618.2
Gene Symbol	IGF1 Somatomedin-C IGF-IB IGF-IA IBP1 MGF IGFI
UniProt Number	P05019
Stem Cell Type	Hematopoietic Stem Cells Mesenchymal Stem Cells

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized IGF-I, though stable at room temperature, is best stored at -20°C for up to 12 months from date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4°C for one week or at -20°C for future use. Reconstituted IGF-I should be stored in undiluted aliquots at -20°C for up to six months. Avoid repeated freeze/thaw cycles.

Storage and Shipping Information

Storage Conditions

The lyophilized IGF-I, though stable at room temperature, is best stored at -20°C for up to 12 months from date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4°C for one week or at -20°C for future use. Reconstituted IGF-I should be stored in undiluted aliquots at -20°C for up to six months. Avoid repeated freeze/thaw cycles.