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Histone H2B human recombinant

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号:03-185

牌:Millipore 密理博

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Replacement Information

重要规格表

Key Applications
KA, DNA-binding Proteins, WB
Description
Catalogue Number 03-185
Brand Family Upstate
Trade Name
  • Upstate
Description Histone H2B human recombinant
Overview Human recombinant H2B expressed in E. Coli
Background Information Histone H2B is one of four core histones that form an octameric structure required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can influence chromatin structure and stability and consequently, transcription, and DNA replication and repair. The most widely studied of these modifications are methylation, phosphorylation, and acetylation which may produce different effects on gene regulation depending on the number and pattern of modifications. Histone H2B undergoes acetylation at lysines 5, 15, and 20. It is also phosphorylated in apoptotic cells during DNA fragmentation, possibly in a caspase-dependent manner.
References
Product Information
Format Purified
Presentation Liquid in Dulbecco's PBS. Frozen solution.
Applications
Application Human recombinant H2B expressed in E. Coli.
Key Applications
  • Kinase Assay
  • DNA-binding Proteins
  • Western Blotting
Application Notes Chromatin assembly, Western blot (control), Kinase Assay
Biological Information
Host E. coli
Purity Purity >95% by SDS-PAGE
Molecular Weight ~17 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 12 months at -80ºC from date of receipt. Avoid multiple freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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