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Qiagen 凯杰 Biosharp Omega

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PCAF, active

市场价：
0.00
促销价：
¥0.00

货号：14-309

品牌：Millipore 密理博

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Replacement Information

重要规格表

Key Applications Entrez Gene Number Uni Prot Number
HAT NM_003884.3 Q92831
Description
Catalogue Number 14-309
Brand Family Upstate
Trade Name
  • Upstate
Description PCAF Protein, Active, 50 µg
Overview Recombinant GST fusion protein
References
Product Information
Applications
Application PCAF recombinant GST fusion protein, for use in Histone Acetyltransferase Assays. (HAT).
Key Applications
  • Histone Acetyltransferase Assay (HAT)
Biological Information
Source expressed in E. Coli corresponding to amino acids 352-832
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Gene Symbol
  • PCAF
  • GCN5
  • GCN5L
  • P
  • P/CAF
  • CAF
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q92831 # Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
SIZE: 832 amino acids; 93013 Da
SUBUNIT: Interacts with SIRT1 (By similarity). Interacts with EP300 and CREBBP. Interacts with NCOA1 and NCOA3. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle.
DOMAIN:SwissProt: Q92831 The bromodomain mediates binding to HIV-1 Tat.
SIMILARITY: Belongs to the GCN5 family. & Contains 1 bromo domain. & Contains 1 N-acetyltransferase domain.
Molecular Weight 79kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by acetylation of core histones in vitro
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -20°C
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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