Recombinant Human M-CSF

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Recombinant Human M-CSF

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货号：GF053

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Key Applications	Species	Source	Purity
CULT	Human	E. coli	Greater than 98% by SDS-PAGE and HPLC analyses

Description
Catalogue Number	GF053
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Macrophage-Colony Stimulating Factor Protein, Recombinant human
Overview	M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is involved in development, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Human M-CSF is a 36.8 kDa disulfide-linked homodimer composed of two 159 amino acid polypeptide subunits.
Alternate Names	Macrophage colony-stimulating factor 1 CSF-1 M-CSF MCSF Lanimostim

References

Product Information
Presentation	The sterile filtered solution was lyophilized from sodium phosphate, pH 8.0 and 75 mM NaCl.

Applications
Application	The M-CSF protein is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts & osteoblasts.
Key Applications	Cell Culture
Application Notes	For most in vitro applications, M-CSF exerts its biological activity in the concentration range of 0.1 to 20.0 ng/mL.

Biological Information
Purity	Greater than 98% by SDS-PAGE and HPLC analyses
Source	E. coli
Specific Activity	The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is < 5 ng/mL, corresponding to a specific activity of > 2 x 10<sup>5</sup> units/mg.
Entrez Gene Number	NM_000757.3 NM_172210.1 NM_172211.1 NM_172212.1
Entrez Gene Summary	The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Four transcript variants encoding three different isoforms have been found for this gene.
Gene Symbol	CSF1 M-CSF MCSF CSF-1 Lanimostim MGC31930
UniProt Number	P09603
UniProt Summary	FUNCTION: SwissProt: P09603 # Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF- 1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. SIZE: 554 amino acids; 60119 Da SUBUNIT: Homodimer or heterodimer; disulfide-linked. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein (By similarity). & Processed macrophage colony-stimulating factor 1: Secreted, extracellular space (By similarity). PTM: Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. & Isoform 1 is N- and O-glycosylated. Isoform 3 is N- glycosylated.
Stem Cell Type	Hematopoietic Stem Cells

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20° C. After a quick spin, reconstitute in water to a concentration of 0.1 - 0.5 mg/mL. Reconstituted M-CSF should be stored in undiluted aliquots at -20° C. Avoid repeated freeze/thaw cycles. This solution can then be further diluted into other buffers and stored at 2° - 8° C for one week or stored at -20° C for future use.

Storage and Shipping Information

Storage Conditions

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20° C. After a quick spin, reconstitute in water to a concentration of 0.1 - 0.5 mg/mL. Reconstituted M-CSF should be stored in undiluted aliquots at -20° C. Avoid repeated freeze/thaw cycles. This solution can then be further diluted into other buffers and stored at 2° - 8° C for one week or stored at -20° C for future use.