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BAFF, Human recombinant

市场价：: 0.00

促销价：: ¥0.00

货号：GF136

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Key Applications	Species	Source	Purity
CULT, Cult	Human	E.coli	Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1 EU/ug) of BAFF.

Description
Catalogue Number	GF136
Brand Family	Chemicon®
Trade Name	Chemicon
Description	BAFF Protein, Recombinant human
Overview	Human BAFF (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family. BAFF plays an important role as co-stimulator of B-cell proliferation and function. Recombinant human BAFF is a soluble 17.0 kDa protein containing 153 amino acid residues, comprising the TNF-like extracellular domain of BAFF.
Alternate Names	B-cell Activation Factor TALL-1 THANK BLyS

References

Product Information
Presentation	Lyophilized from sterile filtered 0.5X PBS, pH 7.5, and 0.5 mM DTT, containing no additives.

Applications
Application	The Human BAFF protein (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family.
Key Applications	Cell Culture Stem Cell Culture

Biological Information
Purity	Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1 EU/ug) of BAFF.
Source	E.coli
Specific Activity	Human BAFF is biologically active when compared to standards. The ED50 as determined by its dose-dependent mitogenic activity on human RPMI 8226 cells is 5-10 ng/mL.
Entrez Gene Number	NM_006573.3
Entrez Gene Summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
Gene Symbol	TNFSF13B BLyS TNFSF20 CD257 BAFF TALL1 DTL TALL-1 ZTNF4 THANK BLYS
UniProt Number	Q9Y275
UniProt Summary	FUNCTION: SwissProt: Q9Y275 # Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. SIZE: 285 amino acids; 31223 Da SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted. TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. PTM: The soluble form derives from the membrane form by proteolytic processing. & N-glycosylated. SIMILARITY: SwissProt: Q9Y275 ## Belongs to the tumor necrosis factor family.
Stem Cell Type	Human Embryonic Stem Cells Induced Pluripotent Stem Cells
Molecular Weight	17.0 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C for up to one year from date of receipt. Reconstituted material can be stored at 2°-8°C for one week, but undiluted aliquots at -20°C are recommended. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	20 µg

Transport Information

Supplemental Information

Specifications

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