Recombinant Mouse IGF-I

Key Applications	Species	Source	Purity
CULT	Mouse	Mouse, expressed in E.coli	Greater than 97% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-I.

Key Applications

Species

Source

Purity

CULT

Mouse

Mouse, expressed in E.coli

Greater than 97% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-I.

Description
Catalogue Number	GF121
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Insulin-like Growth Factor-I Protein, Recombinant mouse
Overview	Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Recombinant Mouse IGF-I is a 7.6 kDa protein containing 70 amino acid residues.
Alternate Names	IGF-I

Description

Catalogue Number

GF121

Brand Family

Chemicon®

Trade Name

Chemicon

Description

Insulin-like Growth Factor-I Protein, Recombinant mouse

Overview

Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Recombinant Mouse IGF-I is a 7.6 kDa protein containing 70 amino acid residues.

Alternate Names

IGF-I

Product Information
Presentation	The sterile filtered solution was lyophilized with no additives.

Product Information

Presentation

The sterile filtered solution was lyophilized with no additives.

Applications
Application	Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone & cartilage tissue.
Key Applications	Cell Culture

Applications

Application

Insulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone & cartilage tissue.

Key Applications

Cell Culture

Biological Information
Purity	Greater than 97% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-I.
Source	Mouse, expressed in E.coli
Specific Activity	The ED50 as determined using FDC-P1 cells is less than <2.0 ng/mL, corresponding to a specific activity of > 5 x 10E5 units/mg.
Entrez Gene Summary	The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM]
Gene Symbol	IGF1A IGF1 IBP1 MGF
UniProt Number	P05019 P05017
UniProt Summary	FUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.\| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. SIZE: 195 amino acids; 21841 Da SUBCELLULAR LOCATION: Secreted. DOMAIN: SwissProt: P05019 DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.\| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.\| P01343 ## Belongs to the insulin family.
Stem Cell Type	Neural Stem Cells Epithelial Cells Mesenchymal Stem Cells

Biological Information

Purity

Greater than 97% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-I.

Source

Mouse, expressed in E.coli

Specific Activity

The ED50 as determined using FDC-P1 cells is less than <2.0 ng/mL, corresponding to a specific activity of > 5 x 10E5 units/mg.

Entrez Gene Summary

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM]

Gene Symbol

IGF1A
IGF1
IBP1
MGF

UniProt Number

UniProt Summary

FUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
SIZE: 195 amino acids; 21841 Da
SUBCELLULAR LOCATION: Secreted.
DOMAIN: SwissProt: P05019
DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.| P01343 ## Belongs to the insulin family.

Stem Cell Type

Neural Stem Cells
Epithelial Cells
Mesenchymal Stem Cells

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted mouse IGF-I should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles.

Storage and Shipping Information

Storage Conditions

The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted mouse IGF-I should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	50 µg

Packaging Information

Material Size

50 µg

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

办公用品

Recombinant Mouse IGF-I

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