Recombinant Hu Soluble TNF Receptor, Type I - 炼石商城

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Recombinant Hu Soluble TNF Receptor, Type I

市场价：: 0.00

促销价：: ¥0.00

货号：GF103

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Culture Supernatant	Monoclonal Antibody

Description
Catalogue Number	MABE1664
Replaces	05-430
Description	Anti-INK4b (p15) Antibody, clone GF10 (10C7A6)
Alternate Names	Cyclin-dependent kinase 4 inhibitor B MTS-2 Multiple tumor suppressor 2 p14-INK4b p15-INK4b p15INK4B
Background Information	Cyclin-dependent kinase 4 inhibitor B (UniProt P42772; also known as MTS-2, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b, p15INK4B) is encoded by the CDKN2B (also known as MTS2) gene (Gene ID 1030) in human. The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation. INK4a and INK4b (encoded by the CDKN2A and CDKN2B gene, respectively) constitute the INK4 subfamily of CDKis. INK4a and INK4b are induced by oncogenic Ras and are involved in cell cycle G1 arrest and cellular senescence. Inactivation of CDKN2A and CDKN2B are found in a wide variety of human malignancies and murine tumor models.

References

Product Information
Format	Culture Supernatant
Presentation	Mouse monoclonal IgG1κ hybridoma culture supernatant with 0.05% sodium azide.

Applications
Application	Anti-INK4b (p15) Antibody, clone GF10 (10C7A6) is an antibody against INK4b (p15) for use in Western Blotting.
Key Applications	Western Blotting

Biological Information
Immunogen	Recombinant full-length human INK4b (p15).
Clone	GF10 (10C7A6)
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone GF10 (10C7A6), Cat. No. MABE1664 and clone GF7 (7CIG4), Cat. No. 05-430 correspond to two independent clones originated from the same mouse host. Clone GF10 (10C7A6) is recommended as an alternative to clone GF7 (7CIG4), however these two clones are expected to recognize different epitopes, exhibit different target-binding affinity and species cross-reactivity. Cross-reactivity of clone GF10 (10C7A6) toward spliced isoform 2 (p10; UniProt P42772-2) has not been confirmed.
Isotype	IgG1κ
Species Reactivity	Human
Species Reactivity Note	Human.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_004927
Gene Symbol	CDKN2B MTS2
Purification Method	Unpurified
UniProt Number	P42772
Molecular Weight	~15 kDa observed. 14.72 kDa (isoform 1; p15) and 8.078 kDa (isoform 2; p10) calculated.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HEK293T cell lysate. Western Blotting Analysis: A 1:250 dilution of this antibody detected INK4b (p15) in 50 µg of HEK293T cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

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