Recombinant Human FGF-4

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Recombinant Human FGF-4

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货号：GF098

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Key Applications	Species	Source	Purity
CULT	Human	E.coli	Greater than 95% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of FGF-4

Description
Catalogue Number	GF098
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Fibroblast Growth Factor-4 Protein, Recombinant human
Overview	The fibroblast growth factors play key roles in controlling tissue growth, morphogenesis and repair in animals. FGF-4 is a heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. GF098 is a 19.7 kDa protein containing 182 amino residues.
Alternate Names	FGF-4

References

Product Information
Presentation	Sterile filtered and then lyophilized from 10 mM Tris, pH 7.4 + 100 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.

Applications
Application	The fibroblast growth factors 4 (or FGF-4 protein) play key roles in controlling tissue growth, morphogenesis & repair in animals.
Key Applications	Cell Culture

Biological Information
Purity	Greater than 95% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of FGF-4
Source	E.coli
Specific Activity	BIOLOGICAL ACTIVITY:The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.
Entrez Gene Number	NM_002007.1
Entrez Gene Summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
Gene Symbol	FGF4 HBGF-4 HST-1 HST KFGF KS3 K-FGF FGF-4 HSTF1
UniProt Number	P08620
UniProt Summary	FUNCTION: SwissProt: P08620 # Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity. SIZE: 206 amino acids; 22048 Da SIMILARITY: SwissProt: P08620 ## Belongs to the heparin-binding growth factors family.
Stem Cell Type	Neural Stem Cells Epithelial Cells Mesenchymal Stem Cells Pancreatic Stem Cells

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized protein can be stored for a few weeks at room temperature but is best stored at -20°C. Reconstituted FGF-4 should be stored in working aliquots at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1mg/ml. This solution can be diluted into other buffer solutions and stored at 2-8°C for 1 week or at -20°C for future use. Freeze/thaw cycles will result in significant loss of activity.

Storage and Shipping Information

Storage Conditions

The lyophilized protein can be stored for a few weeks at room temperature but is best stored at -20°C. Reconstituted FGF-4 should be stored in working aliquots at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1mg/ml. This solution can be diluted into other buffer solutions and stored at 2-8°C for 1 week or at -20°C for future use. Freeze/thaw cycles will result in significant loss of activity.