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Recombinant Rat MCP-1

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货号：GF041

品牌：Millipore 密理博

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Replacement Information

重要规格表

Key Applications Species Source Purity
CULT Rat E.coli Greater than 98% by SDS-PAGE analysis and HPLC analysis.
Description
Catalogue Number GF041
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Monocyte Chemotactic Protein-1, Recombinant rat
Overview Macrophage/monocyte chemoattractant protein-1 (MCP-1) plays an important role in the inflammatory response of blood monocytes and tissue macrophages. Rat MCP-1 is a 14.1 kDa protein containing 125 amino acid residues.
Alternate Names
  • MCP-1
References
Product Information
Presentation Lyophilized protein with no additives. The protein may appear as a haze or film which is difficult to see at the bottom of the vial.
Applications
Application The Macrophage/monocyte chemoattractant protein-1 (or MCP-1 protein) plays an important role in the inflammatory response of blood monocytes & tissue macrophages.
Key Applications
  • Cell Culture
Biological Information
Purity Greater than 98% by SDS-PAGE analysis and HPLC analysis.
Source E.coli
Specific Activity Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
Entrez Gene Number
Entrez Gene Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Gene Symbol
  • CCL2
  • SMC-CF
  • MCAF
  • HSMCR30
  • GDCF-2
  • SCYA2
  • MCP1
  • HC11
  • MGC9434
  • MCP-1
UniProt Number
UniProt Summary FUNCTION: SwissProt: P13500 # Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
SIZE: 99 amino acids; 11025 Da
SUBUNIT: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
SUBCELLULAR LOCATION: Secreted.
PTM: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
SIMILARITY: SwissProt: P13500 ## Belongs to the intercrine beta (chemokine CC) family.
Stem Cell Type
  • Hematopoietic Stem Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions The lyophilized powder, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4°C for one week or -20°C for future use. After reconstitution store in working aliquots at -20°C for up to 6 months.
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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