Recombinant Human IL-11

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Recombinant Human IL-11

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货号：IL011

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Key Applications	Species	Purity
CULT	Human	Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of IL-11.

Description
Catalogue Number	IL011
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Interleukin-11, recombinant
Overview	Interleukin-11 (IL-11) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B-cells and T-cells. Human IL-11 is a 19.1 kDa protein containing 179 amino acid residues.
Alternate Names	IL-11

References

Product Information
Presentation	Sterile filtered and lyophilized with no additives.

Applications
Application	The recombinant Interleukin-11 protein (or IL-11 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells.
Key Applications	Cell Culture
Application Notes	For most in vitro applications, IL-11 exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Certain B-cells and T-cells.

Biological Information
Purity	Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of IL-11.
Specific Activity	The ED(50) as determined by the dose-dependent stimulation of the proliferation of mouse T11 cells is ≤ 2 ng/mL, corresponding to a specific activity of ≥ 5 x 10<sup>5</sup> units/mg.
Entrez Gene Number	NM_000641.2
Entrez Gene Summary	The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
Gene Symbol	IL11 IL-11 oprelvekin Oprelvekin AGIF
UniProt Number	P20809
UniProt Summary	FUNCTION: SwissProt: P20809 # Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. SIZE: 199 amino acids; 21429 Da SUBCELLULAR LOCATION: Secreted. SIMILARITY: SwissProt: P20809 ## Belongs to the IL-6 superfamily.
Stem Cell Type	Hematopoietic Stem Cells

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	The lyophilized powder, though stable for a few weeks at room temperature, is best stored at -20°C. After a quick spin, reconstitute in water to a concentration of 0.5-1.0 mg/mL. Please note: This solution is slow to dissolve. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted IL-11 should be stored in undiluted aliquots at -20°C for up to six months.

Storage and Shipping Information

Storage Conditions

The lyophilized powder, though stable for a few weeks at room temperature, is best stored at -20°C. After a quick spin, reconstitute in water to a concentration of 0.5-1.0 mg/mL. Please note: This solution is slow to dissolve. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted IL-11 should be stored in undiluted aliquots at -20°C for up to six months.