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125I-Ghrelin I-125<55.5KBqs

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号:9088-HK

牌:Millipore 密理博

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Replacement Information
Description
Catalogue Number 9088-HK
Description Ghrelin
Background Information These iodinated hormonos are HPLC purified and prepared fresh monthly.
References
Product Information
Format Iodinated Hormones
Applications
Application Notes appropriate label hydrating buffer if kit replacement or assay buffer of choice
Biological Information
Entrez Gene Number
Entrez Gene Summary Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor (GHSR; MIM 601898) and is involved in regulating growth hormone (GH; MIM 139250) release. Ghrelin is derived from a preprohormone called preproghrelin, which also generates a second peptide called obestatin. Obestatin is an endogenous ligand for the orphan G protein-coupled receptor GPR39 (MIM 602886) and is involved in satiety and decreased food intake.[supplied by OMIM]
Gene Symbol
  • GHRL
  • ghrelin
  • MTLRP
  • obestatin
Radioactive Isotype 125Iodine
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.
Physicochemical Information
Radioactivity <1.5 μCi
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Storage Conditions 2–8 °C
Packaging Information
Material Size 125 tubes
Transport Information
Supplemental Information
Specifications

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