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Qiagen 凯杰 Biosharp Omega

首页细胞生物学检测Millipore 密理博>

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125I-Human Leptin I-125<55.5KBqs

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货号：9081-HK

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 9081-HK
Description Human Leptin
Background Information These iodinated hormonos are HPLC purified and prepared fresh monthly.
References
Product Information
Format Iodinated Hormones
Applications
Application Notes appropriate label hydrating buffer if kit replacement or assay buffer of choice
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
Gene Symbol
  • LEP
  • leptin
  • OB
  • obesity
  • OBS
Radioactive Isotype 125Iodine
UniProt Number
UniProt Summary FUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
SIZE: 167 amino acids; 18641 Da
SUBUNIT: Interacts with SIGLEC6.
SUBCELLULAR LOCATION: Secreted.
DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
Physicochemical Information
Radioactivity <1.5 μCi
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Storage Conditions 2–8 °C
Packaging Information
Material Size 125 tubes
Transport Information
Supplemental Information
Specifications

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