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ChemiScreen™ Membrane Prep Hu Recombinant C3aR

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货号：HTS016M

品牌：Millipore 密理博

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Replacement Information

重要规格表

Species Host Cells Protein Target
Human Chem-2 C3aR
Description
Catalogue Number HTS016M
Brand Family Chemicon®
Trade Name
  • ChemiScreen
  • Chemicon
Description ChemiSCREEN™ C3aR Membrane Preparation
Overview Full-length human C3aR cDNA
Background Information C3a, along with C4a and C5a, is a 77 amino acid anaphylotoxin generated by proteolytic cleavage during activation of the complement pathway (Ember, 1997). The anaphylotoxins strongly promote inflammation by recruiting leukocytes, particularly basophils, eosinophils, neutrophils and monocyte (Martin, 1997). The proinflammatory properties of C3a are mediated by interaction between the peptide and a 7-TM G-protein coupled receptor, C3aR (Crass, 1996). Genetic and pharmacological inhibition of C3a/C3aR interaction indicates an important role for C3aR in allergic asthsma Humbles, 2000; Drouin, 2002). C3a/C3aR also enhances the effect of SDF-1 in promoting retention of haematopoietic stem/progenitor cells within the bone marrow (Rataiczak, 2004). Chemicon's C3aR membrane preps are an ideal tool for screening for compounds that disrupt binding of C3a to C3aR. The membranes have been shown to bind to 125I-labeled C3a with a Kd of 0.06 nM.
References
Product Information
Format Membranes
Presentation Membranes were adjusted to 0.5mg protein/mL in 50 mM Tris-HCL, pH 7.4, 10% glycerol and 1% BSA, rapidly frozen, and stored at -80°C. One vial contains 500 units, where a unit is the amount of membrane that will yield greater than 1000 cpm specific binding of 125I-labeled C3a (0.04 nM input concentration).
Applications
Application Human C3aR GPCR membrane preparation for Radioligand binding Assays.
Key Applications
  • Radioligand binding assay
Application Notes Radioligand binding assay
Biological Information
Concentration 0.5mg/ml
Entrez Gene Number
Gene Symbol
  • C3AR1
  • C3a-R
  • HNFAG09
  • C3AR
  • C3R1
  • AZ3B
GPCR Class A
Host Cells Chem-2
Protein Target C3aR
Target Sub-Family Anaphylotoxin
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16581 # Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
SIZE: 482 amino acids; 53864 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
PTM: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
SIMILARITY: SwissProt: Q16581 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Bmax for [125I]C3a binding: 1.9 pmol/mg protein
Kd for [125I] C3a binding: ~ 0.06 nM
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -70°C for up to 2 years. Do not freeze and thaw.
Packaging Information
Material Size 1 mL
Transport Information
Supplemental Information
Specifications

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