[关闭]
您好！欢迎来到炼石商城   请登录  注册    兼职小伙伴  
我的购物车
0
Qiagen 凯杰 Biosharp Omega

首页抗体Millipore 密理博>

图片仅供参考，请以实物为准
收藏

Anti-Migfilin, clone 43.9 (mouse monoclonal)

市场价：
0.00
促销价：
¥0.00

货号：MAB2618

品牌：Millipore 密理博

配送至：

支付： 账期 货到付款

数量：

EA (预计3-5工作日到货)

亲，想了解价格请QQ咨询客服！

工作时间

周一至周五：9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

浏览了该商品的用户最终购买

RNeasy Mini Kit (50) 50次
RNeasy Mini Kit (50) 50次
3720.00
10ul吸头，透明，袋装，可灭菌 1000支/袋，50袋/箱
10ul吸头，透明，袋装，可灭菌...
85.80
UltraSignal 超敏ECL化学发光底物 50ml + 50ml
UltraSignal 超敏ECL化学发光...
686.00

浏览了该商品的用户还浏览了

QIAfilter Plasmid Maxi Kit (10) -10
QIAfilter Plasmid Maxi Kit (...
3000.00
QIAamp DNA Blood Midi Kit (20) 20次
QIAamp DNA Blood Midi Kit (2...
2680.00
QIAamp UCP Pathogen Mini Kit (50)
QIAamp UCP Pathogen Mini Kit...
4112.00
Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB2618
Description Anti-Migfilin Antibody, clone 43.9
Alternate Names
  • CSX-associated LIM
  • MIG2-interacting protein
  • Mitogen-inducible 2-interacting protein
  • filamin binding LIM protein 1
  • filamin-binding LIM protein-1
  • mitogen-inducible 2 interacting protein
Background Information Migfilin is a recently identified protein involved in linking the plasma membrane to the actin cytoskeleton as a component of cell-cell and cell-ECM adhesions through the binding of filamin proteins and plays a role in the restructuring of the actin cytoskeleton and regulation of cell shape. A widely expressed protein, migfilin is composed of a filamin binding domain found in the N-terminus, a central proline-rich domain, and three LIM domains within the C-terminus. These LIM domains assist in kindlin-2 binding and are necessary components for localization to focal adhesions. Recent studies show that the central proline-rich domain binds to vasodilator-stimulated phosphoproteins, which seem to be a requirement of migfilin’s ability to affect cell migration. The N-terminal domain’s role in binding filamin is what allows migfilin to link with the actin cytoskeleton. Removal of the final LIM domain and the central proline-rich domain results in alternative splicing, and three isoforms of migfilin have been observed. All isoforms are shown to be expressed in kidney, pancreas, lung, placenta, heart and platelets. Isoform 2 has also been observed in brain and skeletal muscle tissue. Levels of migfilin considered to be higher than the normal levels of expression have been associated with human leiomyosarcoma.
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application This Anti-Migfilin Antibody, clone 43.9 is validated for use in WB for the detection of Migfilin.
Key Applications
  • Western Blotting
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human Migfilin.
Epitope Unknown
Clone 43.9
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity The antibody recognizes Migfilin.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Gene Symbol
  • FBLIM1
  • CAL
  • FBLP-1
  • FBLP1
  • Migfilin
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly.

SUBUNIT STRUCTURE: Isoform 1 and isoform 3 interact with PLEKHC1, FLNA and FLNC. Isoform 2 interacts with FLNB. Interacts with NKX2-5 by similarity.

SUBCELLULAR LOCATION: Cytoplasm › cell cortex. Cell junction › focal adhesion. Cytoplasm › cytoskeleton. Note: Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with PLEKHC1. Isoform 2 is localized at actin stress fibers.

TISSUE SPECIFICTY: Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.

SEQUENCE SIMILARITIES: Contains 3 LIM zinc-binding domains.
Molecular Weight ~ 41 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected Migfilin in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知，且每位咨询者购买情况、提问时间等不同，为此以下回复仅对提问者3天内有效，其他网友仅供参考！若由此给您带来不便请多多谅解，谢谢！

我要咨询

咨询内容：
购物指南 免费注册 批量采购 购物流程 购物保障
配送方式 上门自提 第三方配送 炼石配送
支付方式 货到付款 账期付款
售后服务 售后政策 退款说明 售后流程 免责条款

服务热线

0771-3293894

关于我们|帮助中心|诚聘英才|炼石云实验室|联系我们|友情链接

Copyright 2014-2025 炼石云商网络科技（海南）有限公司版权所有 琼ICP备2023006525号-3