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HIPK1, active 250ug

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货号：14-679M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-679
Brand Family Upstate
Trade Name
  • Upstate
Description HIPK1 Protein, active, 10 µg
Overview N-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555.
References
Product Information
Applications
Application Active, N-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source HIPK1 expressed by baculovirus in Sf21 cells.
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
Gene Symbol
  • HIPK1
  • MGC33446
  • KIAA0630
  • Nbak2
  • MGC26642
  • MGC33548
  • Myak
Protein Target HIPK1
Purification Method Ni2+/NTA-agarose
Target Sub-Family CMGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q86Z02 # May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.
SIZE: 1210 amino acids; 130843 Da
SUBUNIT: Interacts with Nkx1-2 and Nkx2-5 (By similarity). Interacts with DAXX and TP53.
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.
TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.
PTM: Autophosphorylated. Phosphorylated and activated by JNK1.
SIMILARITY: SwissProt: Q86Z02 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain.
Molecular Weight 49.6kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of MBP (13-104).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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