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Qiagen 凯杰 Biosharp Omega

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LOK, active 250ug

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货号：14-686M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-686
Brand Family Upstate
Trade Name
  • Upstate
Description LOK Protein, active, 10 µg
Overview N-terminal 6His-tagged, recombinant human LOK amino acids 1-348
References
Product Information
Applications
Application Active, N-terminal 6His-tagged, recombinant human LOK amino acids 1-348, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
Gene Symbol
  • STK10
  • PRO2729
  • LOK
Protein Target LOK
Purification Method Ni2+/NTA-agarose
Target Sub-Family STE
UniProt Number
UniProt Summary FUNCTION: SwissProt: O94804 # Can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues (By similarity).
SIZE: 968 amino acids; 112135 Da
TISSUE SPECIFICITY: Expressed predominantly in lymphoid organs.
PTM: Autophosphorylated (By similarity).
SIMILARITY: SwissProt: O94804 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain.
Molecular Weight 43.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of Axltide (Catalog# 12-516)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions stable 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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