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Custom peptide

市场价：: 0.00

促销价：: ¥0.00

货号：883060

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₃H₉N₅O₅S₂	883065-90-5

Description
Overview	A cell-permeable benzodioxin-triazole compound that competes with JNK-interacting protein-1 (IC₅₀ = 500 nM in competitive binding to JNK1 with pepJIP1) and D-domain-containing substrates binding (K_i = 200 nM in competitive binding to JNK1 with ATF2) by targeting JNK JIP1-interacting site (K_d = 8.1 µM). BI-78D3 inhibits the phosphorylation of ATF2, but not that of a D-domain-less peptide substrate, by JNK1 in kinase assays, while showing 100-fold less potency against p38α and no effect against mTOR or PI3-Kα. Shown to inhibit the TNF-α-stimulated GFP-cJun phosphorylation in transfected HeLa cultures in vitro (IC₅₀ = 12.4 µM) and effectively reduce ConA-induced murine liver failure (10 mg/kg, i.p.) as well as restore insulin sensitivity in a murine type 2 diabetes model (25 mg/kg, i.p.) in vivo.
Catalogue Number	420140
Brand Family	Calbiochem®
Synonyms	4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-(5-nitrothiazol-2-ylthio)-4H-1,2,4-triazol-3-ol

References
References	Stebbins, J.L., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 16809.

Product Information
CAS number	883065-90-5
Form	Pale yellow solid
Hill Formula	C₁₃H₉N₅O₅S₂
Chemical formula	C₁₃H₉N₅O₅S₂
Structure formula Image

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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