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Anti-CD11c (mouse), Biotin, clone N418

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货号：MABF373

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M IP, IHC, IF, FC AHm Biotin Monoclonal Antibody
Description
Catalogue Number MABF373
Description Anti-CD11c Antibody (mouse), Biotin, clone N418
Alternate Names
  • Integrin alpha-Xl
  • CD11 antigen-like family member C
  • Leukocyte adhesion glycoprotein p150,95 alpha chain
  • Leukocyte adhesion receptor p150,95
  • CD11c
Background Information The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling throµgh ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
References
Product Information
Format Biotin
Presentation Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Applications
Application This armenian hamster monoclonal antibody Anti-CD11c (mouse), Biotin, clone N418 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD11c.
Key Applications
  • Immunoprecipitation
  • Immunohistochemistry
  • Immunofluorescence
  • Flow Cytometry
Biological Information
Immunogen Immunogen information for this antibody is proprietary information.
Clone N418
Concentration 0.5 mg/mL
Host Armenian Hamster
Isotype IgG
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Gene Symbol
  • Itgax
Purification Method Size Exclusion Chromatography
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.03 µg of this antibody detected CD11c in one million C57Bl/6 splenocytes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size 500 µg
Transport Information
Supplemental Information
Specifications

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