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44-TIMP-1 beads MILLIPLEX - COLD PACKS

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货号：RTIMP1

品牌：Millipore 密理博

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Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
B, Eq, Ft, R, Rb, Sh	ELISA, WB, IHC	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB770
Replaces	04-1133
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-TIMP-1 Antibody
Alternate Names	Tissue Inhibitor of Metalloproteinase-1

References

Product Information
Format	Affinity Purified
Presentation	Purified immunoglobulin. Liquid in PBS containing 0.02% azide.

Applications
Application	Anti-TIMP-1 Antibody detects level of TIMP-1 & has been published & validated for use in ELISA, WB, IH.
Key Applications	ELISA Western Blotting Immunohistochemistry
Application Notes	Western Blotting at 5-10 μg/mL: recognizes a band of approximately 28-30kDa in reduced samples. Immunohistochemistry: frozen and 4%PFA fixed paraffin sections: 5-20μg/mL enzymatic detection. Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Full length purified human fibroblast tissue inhibitor of metalloproteinases {Clark, IM (1991) Matrix 11:76-85}.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Reacts with TIMP1. Does not react with any other human proteins tested so far. The antibody reacts with native and denatured TIMP1 and TIMP1 in and out of enzyme/inhibitor complex.
Species Reactivity	Bovine Horse Ferret Rat Rabbit Sheep
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_003254.2
Entrez Gene Summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Gene Symbol	TIMP1 TIMP FLJ90373 CLGI EPA EPO TIMP-1 HCI
UniProt Number	P01033
UniProt Summary	FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. SIZE: 207 amino acids; 23171 Da SUBCELLULAR LOCATION: Secreted. PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds. SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain refrigerated at 2-8°C for up to three months from date of receipt. For extended storage, freeze in convenient undiluted aliquots at -20°C for up to twelve months from date of receipt. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

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