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Qiagen 凯杰 Biosharp Omega

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货号：MXBD-3

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC, IHC, IP Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABE293
Description Anti-MBD3 Antibody
Alternate Names
  • Methyl-CpG-binding domain protein 3
  • Methyl-CpG-binding protein MBD3
Background Information DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, regulates gene expression and is critical for proper development. Human proteins MBD3, MECP2, MBD1, MBD2, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD3 is a component of the Nucleosome Remodeling and Histone Deacetylation (NuRD) complex, which functions as a co-repressor, mediating gene silencing under different cellular contexts. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. MBD1, MBD2, MBD3, and MBD4 are expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity.
References
Product Information
Format Affinity Purified
Control
  • HeLa nuclear extract
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-MBD3 Antibody is an antibody against MBD3 for use in Western Blotting, ICC, IHC, Immunoprecipitation.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunoprecipitation
Application Notes Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated MBD3 from HeLa RIPA lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human MBD3.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes both isoforms of MBD3.
Species Reactivity
  • Human
Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, and Rhesus Macaque based on 100% sequence homology. Other homologies: Bovine (83% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MBD3
Purification Method Affinity Purfied
UniProt Number
Molecular Weight ~32-34 kDa observed. Uniprot describes two isoforms at ~29 and ~33 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 0.2 µg/mL of this antibody detected MBD3 in 10 µg of HeLa nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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