Milliplex Mouse Th17 Premixed 25 Plex Magnetic Bead Panel

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Milliplex Mouse Th17 Premixed 25 Plex Magnetic Bead Panel

市场价：: 49.00

促销价：: ¥0.00

货号：MT17MAG47K-PX25

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Analytes Available	Species Reactivity	Key Applications	Detection Methods
CD40 Ligand, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, IL-15, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27, IL-28B, IL-31, IL-33, MIP-3α/CCL20, TNF-α, TNFβ	M	Mplex	Luminex xMAP

Description
Catalogue Number	MT17MAG47K-PX25
Trade Name	MILLIPLEX
Description	MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Premixed 25 plex - Immunology Multiplex Assay
Overview	The MILLIPLEX MAP Mouse Th17 Magnetic Bead panel enables you to focus on the therapeutic potential of the modulation of CD4 T-helper cell cytokines. Coupled with the Luminex® xMAP® platform in a magnetic bead format, you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of dozens of analytes simultaneously, which can dramatically improve productivity.
Background Information	CD4 T-helper cells are major players in adaptive immunity. Based on their expression profile of transcription factors and secreted cytokines, these cells are divided into the major subsets Th1, Th2, Th17 and T regulatory (Treg) cells. Th1 cells, induced by IL-12 and enhanced by IFN, secrete IFN that activates macrophages. Induced by IL-4, Th2 cells primarily produce IL-4, IL-5, IL-13, IL-25 and IL-17E, playing a role in allergy. Treg cells, induced by TGFβ, produce the anti-inflammatory cytokines IL-10 and TGFβ and function to control T-cell responses to prevent autoimmune reactions. Th17 cells, a more recently discovered subset characterized by the production of IL-17, are induced by TGFβ combined with IL-23 and IL-1β in humans, and TGFβ, IL-6 and IL-21 in mice. Activated Th17 cells secrete IL-17A, IL-17F, IL-21, IL-22 and TNFα to promote tissue inflammation. Th17 cells are involved in the clearance of extracellular bacteria and fungi. They are abundant in the intestinal lamina propria and function as a barrier against invading pathogens. Excessive amounts of Th17 cells have been implicated in the pathogenesis of several autoimmune diseases, including multiple sclerosis, psoriasis, juvenile diabetes, rheumatoid arthritis, Crohn's disease and autoimmune uveitis. In addition Th17 cells play an important role in tumor development, progression and metastasis, potentially in both promoting and inhibiting tumor growth.

References

Product Information
Detection method	Luminex xMAP
Configuration	Premixed
Precision, %	Inter-assay: < 15 Intra-assay:< 10
Panel Type	MAGNETIC Cytokines/Chemokines

Applications
Application	Simultaneously analyze multiple Th17 cytokine and chemokine biomarkers with the Th17 Bead-Based Multiplex Assays using the Luminex technology, in human serum, plasma and cell culture samples.
Key Applications	Multiplexing
Application Notes	• This is a two-hour or overnight incubation assay requiring 25 µL of neat plasma or serum, or 25 μL cell culture supernatant per well. • This kit may be used for the analysis of all or any combination of the Th17 panel analytes in serum, plasma or tissue/cell lysate and culture supernatant

Biological Information
Specificity	Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Species Reactivity	Mouse
Analytes Available	CD40 Ligand GM-CSF IFN-γ IL-1β IL-2 IL-4 IL-5 IL-6 IL-10 IL-12 (p70) IL-13 IL-15 IL-17A IL-17E/IL-25 IL-17F IL-21 IL-22 IL-23 IL-27 IL-28B IL-31 IL-33 MIP-3α/CCL20 TNF-α TNFβ
Cross Reactivity	There was no or minimum cross-reactivity between the antibodies and any other analytes in the panel (see details in assay protocol).
Accuracy	85 - 110%

Physicochemical Information
Sensitivity	Refer to kit protocol for sensitivities of individual biomarkers.
Linearity of Dilution	1:4 111.0% 1:8 113.1%
Standard Curve Range	CD40L IL-31 & MIP-3α: 49 – 50,000 pg/mL GM-CSF & IL-15: 34 – 35,000 pg/mL IFNγ & IL-6: 7.8 – 8,000 pg/mL IL-1β: 15 – 15,000 pg/mL IL-2: 6.9 – 6,000 pg/mL IL-4: 1.5 – 1,500 pg/mL IL-5: 4.9 – 5,000 pg/mL IL-10, IL-12(p70), & IL-21:20 – 20,000 pg/mL IL-13 & IL-17A: 39 – 40,000 pg/mL IL-17E/ IL-25: 586 – 600,000 pg/mL IL-17F: 10 – 10,000 pg/mL IL-22: 2.4 – 2,500 pg/mL IL-23: 342 -350,000 pg/mL IL-27: 879 – 900,000 pg/mL IL-28B: 127 – 130,000 pg/mL IL-33: 78 – 80,000 pg/mL TNFβ:488 – 500,000 pg/mL TNFα: 3.4 – 3,500 pg/mL

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Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Recommended storage for kit components is 2 - 8°C.

Packaging Information
Material Size	96-well plate

Transport Information

Supplemental Information

Specifications

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Milliplex Mouse Th17 Premixed 25 Plex Magnetic Bead Panel

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