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78 - MMP-12 Beads - Magnetic

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货号：MMMP12-MAG

品牌：Millipore 密理博

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Replacement Information

重要规格表

Analytes Available Species Reactivity Key Applications Detection Methods
MMP-2, MMP-3, MMP-8 M Mplex Luminex xMAP
Description
Catalogue Number MMMP1MAG-79K
Trade Name
  • MILLIPLEX
Description MILLIPLEX MAP Mouse MMP Magnetic Bead Panel 1
Overview MILLIPLEX MAP Mouse MMP Magnetic Bead Panel 1 is a 3 plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum/plasma samples: MMP-2, MMP-3 and MMP-8.
Background Information The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs’ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in autoimmune disease, arthritis, cardiovascular disease, and tumor growth and metastasis.
References
Product Information
Detection method Luminex xMAP
Configuration Design your multiplex kit by choosing available analytes within this panel.
Precision, %
  • Intra-assay:< 10
  • Inter-assay: < 20
Panel Type MAGNETIC Cytokines/Chemokines
Applications
Application TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in mouse serum, plasma and cell culture samples.
Key Applications
  • Multiplexing
Application Notes • This is an overnight incubation at 4 ºC or 2-hour incubation at room temperature assay requiring 25 µL of 1:100 dilution of plasma or serum.
• An overnight incubation (16-18 h) may improve assay sensitivity for some analytes.
• This kit may be used for the analysis of all or any combination of the Mouse MMP Panel 1 analytes in serum or plasma.
Biological Information
Specificity Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Species Reactivity
  • Mouse
Analytes Available
  • MMP-2
  • MMP-3
  • MMP-8
Physicochemical Information
Sensitivity
  • See protocol for sensitivities of individual analytes
Standard Curve Range
  • MMP-2: 49 – 200,000 pg/mL
  • MMP-3: 2 – 10,000 pg/mL
  • MMP-8: 12 – 50,000 pg/mL
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Recommended storage for kit components is 2 - 8°C.
Packaging Information
Material Size 96-well plate
Transport Information
Supplemental Information
Specifications

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