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Qiagen 凯杰 Biosharp Omega

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Assay Buffer - Milliplex

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货号：L-AB4

品牌：Millipore 密理博

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Replacement Information

特卖

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB1820
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Scribble Antibody
Alternate Names
  • Scrib
  • LAP4
Background Information Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation Purified in PBS containing with 0.05% NaN3.
Applications
Application This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
Key Applications
  • Western Blotting
Application Notes Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Biological Information
Immunogen GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
Epitope PDZ2 domain of Scribble
Clone 7C6.D10
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity PDZ2 domain of Scribble
Isotype IgG1κ
Species Reactivity
  • Human
Species Reactivity Note Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SCRIB
  • SCRB1
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: May be required for polarization of epithelia
SUBUNIT: Interacts through its PDZ domains with VANGL2. Interacts with UBE3A, HPV E6 and LPP.
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note: Localized to cell junctions
SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
Molecular Weight 220 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Western blot on HeLa cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C for up to 1 year after date of receipt.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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