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Qiagen 凯杰 Biosharp Omega

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6-Plex NF-kB Signaling Magnetic Bead Kit

价:
17.00
价:
¥0.00

号:48-630MAG

牌:Millipore 密理博

账期 货到付款

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Analytes Available Species Reactivity Key Applications Detection Methods
c-Myc, FADD (Ser194), IκBα (Ser32), IKKα/β (Ser177/Ser181), NFκB (Ser536), TNFR1 H Mplex Luminex xMAP
Description
Catalogue Number 48-630MAG
Trade Name
  • MILLIPLEX
Description MILLIPLEXMAP NF-κB Signaling Magnetic Bead Kit 6-plex Kit - Cell Signaling Multiplex Assay
Overview NF-κB (nuclear factor kappa B) is a transcription factor that plays a regulatory role in several physiological and pathological processes. The NF-κB pathway can be activated by numerous stimuli, including inflammatory cytokines, virus, bacteria, UV radiation, genotoxic stress, DNA damage, oxidative stress, etc. The IkBα/NF-κB complex is tightly regulated by both phosphorylation and ubiquitination. Phosphorylation and ubiquitination of IκBα leads to its degradation and subsequent release of phosphorylated NF-κB to the nucleus. Greater than 100 target genes, including cytokines, cyclins, p21, Bcl-2, and c-Myc are known to be transcribed by NF-kB.
References
Product Information
Detection method Luminex xMAP
Configuration Premixed
Panel Type Cell Signaling
Applications
Application Intracellular Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous relative quantitation of multiple phosphorylation and total pathway proteins in tissue and cell lysate samples. Compare Multiplexing results to those of Western blotting.
Key Applications
  • Multiplexing
Application Notes o This is an overnight (4°C) incubation assay.
o This kit must be run using the provided Assay Buffer.
o This assay requires 25 μL diluted filtered cell lysate per well.
o The suggested working range of protein concentration for the assay is 1 to 25 µg of total protein/well (25 µL/well at 40 to 1,000 µg/mL).
Biological Information
Specificity Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Species Reactivity
  • Human
Analytes Available
  • c-Myc
  • FADD (Ser194)
  • IκBα (Ser32)
  • IKKα/β (Ser177/Ser181)
  • NFκB (Ser536)
  • TNFR1
Assay Panel Premixed beads for your convenience.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Recommended storage for kit components is 2 - 8°C.
Packaging Information
Material Size 96-well plate
Material Package 96-well plate
Transport Information
Supplemental Information
Specifications

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