Replacement Information |
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Analytes Available | Species Reactivity | Key Applications | Detection Methods |
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PARP (Cleaved) | H | Mplex | Luminex xMAP |
Description | |
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Catalogue Number | 46-656MAG |
Replaces | MILLIPLEX Late Apoptosis-- 3 Plex (Cat. No. 48-670MAG) |
Trade Name |
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Description | MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex |
Overview | Apoptosis, programmed cell death, is a tightly controlled process involved in both embryonic development and adult homeostasis in which the body is able to rid itself of damaged or unnecessary cells without inducing an inflammatory response. This essential process is triggered by both internal (DNA damage, mitochondrial dysfunction) and external (Fas and TNF receptor) signals. Dysregulated apoptosis that results in accelerated programmed cell death has been implicated in the development of various neurological diseases, such as Alzheimer’s and Parkinson’s disease, while inhibition of apoptosis is involved in the development of autoimmune disorders and cancer. |
Materials Required but Not Delivered | • MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog #48-602) |
Background Information | Cleaved PARP • Also known as Poly (ADP-ribose) polymerase • Involved in programmed cell death and DNA repair • PARP is inactivated by caspase cleavage at aspartic acid 214 and glycine 215, separating PARP into 2 segments; this Cleaved PARP ends at Asp 214, and contains the DNA binding domain |
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Product Information | |
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Detection method | Luminex xMAP |
Configuration | Single Plex |
Panel Type | Cell Signaling |
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Material Size | 96-well plate |
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Specifications |
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