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Human Apolipoprotein C-III

市场价：: 0.00

促销价：: ¥0.00

货号：ALP60-100UG

品牌：Millipore 密理博

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Replacement Information

Description
Catalogue Number	ALP60-100UG
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Apolipoprotein C-III, human
Overview	MOLECULAR WEIGHT: 8,750
Alternate Names	ApoCIII
Background Information	The physiological role of Apo CIII is unknown. It is suggested that Apo CIII may inhibit the activation of lipoprotein lipase by Apo CII.

References

Product Information
Presentation	Liquid in 10 mM NH4HCO3, pH 7.4.

Applications
Key Applications	Positive Control

Biological Information
Purity	> 95% by SDS-PAGE
Source	Human plasma tested negative for HBsAg and HIV-I, HIV-II, HBc and Hepatitis C antibodies. All blood products should be treated as potentially infectious.
Entrez Gene Number	NM_000040.1
Entrez Gene Summary	Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
Gene Symbol	APOC3 ApoC-III Apo-CIII APOCIII MGC150353
UniProt Number	P02656
UniProt Summary	FUNCTION: SwissProt: P02656 # Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. SIZE: 99 amino acids; 10852 Da SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine. PTM: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. DISEASE:SwissProt: P02656 # Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). SIMILARITY: SwissProt: P02656 ## Belongs to the apolipoprotein C3 family.

Physicochemical Information

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Toxicological Information

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Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20ºC or below in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. All blood products should be treated as potentially infectious.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

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