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Human Integrin a3b1,Octyl-b-D-Glucopyranoside

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货号：CC1092

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number CC1092
Replaces CC1029
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human
Overview Integrin alpha3beta1 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alpha3beta1 integrin.
References
Product Information
Presentation Purified protein in 150 Mm NaCl, 0.1 mM CaCl2, 1 mM MgCl2, 25 mM Tris-HCL, pH 7.4, 100 mM Octyl-b-D-glucopyranoside. No preservatives.
Applications
Key Applications
  • ELISA
  • Western Blotting
  • Activity Assay
  • Immunoelectrophoresis
Application Notes Electrophoresis, Immunoblotting, and Ligand Binding studies.

Optimal working dilutions must be determined by end user.
Biological Information
Purity >95% by SDS-PAGE
Entrez Gene Number
Entrez Gene Summary ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
Gene Symbol
  • ITGA3
  • GAP-B3
  • CD49c
  • FLJ34704
  • MSK18
  • VLA3a
  • VL3A
  • VCA-2
  • FLJ34631
  • FRP-2
  • GAPB3
  • CD49C
UniProt Number
UniProt Summary FUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
SIZE: 1066 amino acids; 118698 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation.
SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles
Packaging Information
Material Size 25 µg
Transport Information
Supplemental Information
Specifications

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