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Rb Melanocortin Receptor 2

市场价：: 0.00

促销价：: ¥0.00

货号：AB5128

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	ELISA, WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB5128
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Melanocortin Receptor-2 Antibody
Background Information	Mouse Melanocortin receptor 2 (MC2-R or ACTH-R) is a 297 aa transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for ACTH. It is found in melanocyte and corticoadrenal tissues. Defects in insensitivity or resistance to ACTH and characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.

References

Product Information
Format	Affinity Purified
Presentation	Affinity Purified 1mg/mL solution in PBS, with 0.1% BSA.

Applications
Application	This Anti-Melanocortin Receptor-2 Antibody is validated for use in ELISA, WB for the detection of Melanocortin Receptor-2.
Key Applications	ELISA Western Blotting
Application Notes	Western blot: 1-10 μg/mL using Chemiluminescence technique ELISA: 1:10,000 - 100,000 Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	A 17 aa peptide (designated MCR21) from the 4th cytoplasmic domain of mouse MC2-R.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Species Reactivity	Human Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_000529.2
Entrez Gene Summary	MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
Gene Symbol	MC2R ACTH-R ACTHR MGC125798 MC2-R
UniProt Number	Q01718
UniProt Summary	FUNCTION: SwissProt: Q01718 # Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. SIZE: 297 amino acids; 33927 Da SUBUNIT: Interacts with FALP/MRAP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue. DISEASE: SwissProt: Q01718 # Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. SIMILARITY: SwissProt: Q01718 ## Belongs to the G-protein coupled receptor 1 family.

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Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

Packaging Information
Material Size	50 µg

Transport Information

Supplemental Information

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