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TACE, C-Terminal Control Peptide

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货号：AG909

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number AG909
Brand Family Chemicon®
Trade Name
  • Chemicon
Description ADAM 17, control peptide for AB19027
Overview The peptide is used for blocking the activity of anti-TACE, C-Terminal (Catalog number AB19027). Incubate the peptide with equal volume of antibody for 30 minutes at 37oC to block the activity of anti-TACE in Western blotting. Amino Acids 807 to 823 (ASFKLQRQNRVDSKETE) of human TACE (Black et al. 1997; Moss et al. 1997).
Alternate Names
  • TACE
  • CD156b
References
Product Information
Presentation Liquid in PBS containing 0.1% BSA and 0.02% sodium azide.
Applications
Key Applications
  • Peptide Inhibition Assay
Application Notes For use in blocking the reactivity of AB19027.

Optimal working dilution must be determined by the end user.
Biological Information
Concentration 200 μg/mL
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
Gene Symbol
  • ADAM17
  • MGC71942
  • cSVP
  • CSVP
  • CD156b
  • TACE
  • CD156B
  • EC 3.4.24.86
UniProt Number
UniProt Summary FUNCTION: SwissProt: P78536 # Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
COFACTOR: Binds 1 zinc ion per subunit.
SIZE: 824 amino acids; 93021 Da
SUBUNIT: Interacts with MAD2L1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
DOMAIN: SwissProt: P78536 Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity). & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
PTM: The precursor is cleaved by a furin endopeptidase (By similarity). & Phosphorylated. Stimulation by growth factor or phorbol 12- myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791.
SIMILARITY: Contains 1 disintegrin domain. & Contains 1 peptidase M12B domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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