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Anti-PINK1, clone N4/49 (mouse monoclonal)

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货号：MABN18

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IHC, WB M Purified Monoclonal Antibody
Description
Catalogue Number MABN18
Description Anti-PINK1 Antibody, clone N4/49
Alternate Names
  • PTEN induced putative kinase 1
  • protein kinase BRPK
  • serine/threonine-protein kinase PINK1
  • PTEN-induced putative kinase protein 1
  • Parkinson disease (autosomal recessive) 6
Background Information Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
References
Product Information
Format Purified
Control
  • Human normal brain tissue
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-PINK1 Antibody, clone N4/49 is validated for use in IH, WB for the detection of PINK1.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application Notes Western Blot Analysis: A previous lot of MABN18 recognized PINK1 in HEK cells and a rat brain LSP, as reported by an independent laboratory (UC Davis/NIH NeuroMab Facility; www.neuromab.org/neuromab@ucdavis.edu).
Biological Information
Immunogen Recombinant protein corresponding to human PINK1.
Clone N4/49
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes PINK1.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq].
Gene Symbol
  • PINK1
  • PARK6
  • BRPK
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

COFACTOR: Magnesium.

SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein.

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.

PTM: Autophosphorylated.

INVOLVEMENT IN DISEASE: Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.
Molecular Weight 63 kDa Observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in human normal brain tissue.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected PINK1 in human normal brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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