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Anti-SMURF2 (rabbit polyclonal)

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货号：ABS59

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Po, B, Ch, Chp, Xn WB, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS59
Description Anti-SMURF2 Antibody
Alternate Names
  • Smad ubiquitin regulatory factor 2
  • SMAD specific E3 ubiquitin protein ligase 2
  • SMAD-specific E3 ubiquitin-protein ligase 2
  • E3 ubiquitin ligase SMURF2
Background Information SMURF2 (Smad ubiquitin regulatory factor 2) is a SMAD specific E3 ubiquitin protein ligase. Both SMURF2 and Smad ubiquitin regulatory factor 1 (SMURF1) play an important role in TFG-β signaling and are known to suppress transforming growth factor-beta (TGF-beta) family signaling. Mutations in SMURF2 have been associated with tumor formation. SMURF2 is known to interact with SMAD1, SMAD2 and SMAD7 to promote ubiquitination and proteasome-dependent degradation of these proteins. SMURF2 interacts with all members of the Smad family except Smad4. This protein is expressed in a variety of tissues and cell lines.
References
Product Information
Format Affinity Purified
Control
  • MCF-7 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-SMURF2 Antibody is validated for use in WB, IH for the detection of SMURF2.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: 1:400 dilution from a representative lot detected SMURF2 in ductal carcinoma in situ and infiltrating ductal carcinoma tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the WW 1 domain of human SMURF2.
Epitope WW 1 domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes SMURF2.
Species Reactivity
  • Human
  • Mouse
  • Pig
  • Bovine
  • Chicken
  • Chimpanzee
  • Xenopus
Species Reactivity Note Demonstrated to react with human. Predicted to react with rat, mouse, pig, cow, chicken, chimpanzee, and Xenopus based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SMURF2
  • hSMURF2
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

SIZE: 748 amino acids; 86196 Da

SUBUNIT: Interacts with SMAD1, SMAD2, SMAD3, SMAD6 and SMAD7 but not SMAD4.

SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic in the presence of SMAD7.

TISSUE SPECIFICITY: Widely expressed.

DOMAIN: The second and third WW domains are responsible for interaction with R-SMAD (SMAD1, SMAD2 and SMAD3).

SIMILARITY: Contains 1 C2 domain. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 3 WW domains.
Molecular Weight ~ 80 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in MCF-7 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected SMURF2 on 10 µg of MCF-7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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