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Rb X Synapsin, phospho Serine 62,67

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货号：AB9848

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9848
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-phospho-Synapsin I (Ser62,Ser67) Antibody
References
Product Information
Format Affinity Purified
Presentation Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/mL BSA and 50% glycerol.
Applications
Application Anti-phospho-Synapsin I Antibody (Ser62, Ser67) detects level of phospho-Synapsin I (Ser62) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Synthetic peptide of amino acids surrounding the phosphoSerine 62,67 site of rat Synapsin I.
Host Rabbit
Specificity Synapsin I, phospho Serine 62,67. The antibody recognizes a protein doublet of ~78 kDa corresponding to Synapsin I, phospho Serine 62,67 in lysates from rat cortex. Immunolableing is blocked by preadsorption with the phospho-peptide used as the immunogen but not by the corresponding dephospho-peptide.
Species Reactivity
  • Rat
Species Reactivity Note The immunogen has 100% homology with mouse and bovine.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol
  • SYN1
  • SYN1a
  • Synapsin-1
  • SYNI
  • SYN1b
Modifications
  • Phosphorylation
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
SIZE: 705 amino acids; 74111 Da
SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse.
PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].
SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20degC in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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