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Anti-SUZ12, clone 3C1.2

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货号：04-046

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number 04-046
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SUZ12 Antibody, clone 3C1.2
Background Information SUZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation 100 μg of Protein A purified mouse monoclonal IgG1κ in 100 μL of 1X PBS, pH 7, 0.1% Azide.
Applications
Application Anti-SUZ12 Antibody, clone 3C1.2 is a high quality Mouse Monoclonal Antibody for the detection of SUZ12 & has been validated in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Full length, recombinant human SUZ12.
Clone clone 3C1.2
Host Mouse
Specificity SUZ12
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.
Gene Symbol
  • SUZ12
  • KIAA0160
  • CHET9
  • JJAZ1
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q15022 # Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
SIZE: 739 amino acids; 83055 Da
SUBUNIT: Component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2.
SUBCELLULAR LOCATION: Nucleus (Probable).
DISEASE: SwissProt: Q15022 # A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.
SIMILARITY: SwissProt: Q15022 ## Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. & Contains 1 C2H2-type zinc finger.
Molecular Weight 95 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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