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Qiagen 凯杰 Biosharp Omega

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Rb X K2p 4.1 (TRAAK)

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号:AB9830-200UL

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R IHC, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9830-200UL
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-K2P4.1 Antibody
Alternate Names
  • TRAAK
  • TWIK-related arachidonic acid-stimulated K+ channel
  • KCNK4
References
Product Information
Format Affinity Purified
Control
  • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
Presentation Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
Applications
Application This Anti-K2P4.1 Antibody is validated for use in IH, WB for the detection of K2P4.1.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application Notes Western blot: 1:200 using ECL on rat cerebellum lysate and HEK- K2P4.1 transfected cells.

Immunohistochemistry on rat brain sections.

Dilutions should be made using a carrier protein such as BSA (1-3%).

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Purified peptide from amino acids 343-359 of human K2P4.1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes K2P4.1 (TRAAK, TWIK-related arachidonic acid-stimulated K+ channel, KCNK4).
Isotype IgG
Species Reactivity
  • Rat
Species Reactivity Note The immunogen sequence is identical in mouse, rat and canine.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.
Gene Symbol
  • KCNK4
  • TRAAK
  • K2p4.1
  • TRAAK1
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9NYG8 # Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations (By similarity).
SIZE: 393 amino acids; 42704 Da
SUBUNIT: Homodimer (Potential).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: SwissProt: Q9NYG8 ## Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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