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CASP 3 FLUOROMETRIC 5MG

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货号：12-323

品牌：Millipore 密理博

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Replacement Information

重要规格表

Key Applications Detection Methods
ACT Fluorescent
Description
Catalogue Number 12-323
Brand Family Upstate
Trade Name
  • Upstate
Description Caspase 3 Fluorometric Substrate
References
Product Information
Detection method Fluorescent
Presentation Lyophilized powder.
Applications
Application Caspase 3 Fluorometric Substrate (Ac-Asp-Glu-Val-Asp-AMC) for use in Capase activity assays. Can be used to assay Apopain activity in vitro.
Key Applications
  • Activity Assay
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Gene Symbol
  • CASP3
  • apopain
  • CASP-3
  • procaspase3
  • CPP32B
  • SCA-1
  • CPP-32
  • Apopain
  • CPP32
  • Yama
UniProt Number
UniProt Summary FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
SIZE: 277 amino acids; 31608 Da
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated in an Apopain activity assay as described in (Nicholson, D.W., et al., Nature 376: 37-43, 1995).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Lypholized: 2 years at -20°C. Rehydrated: 4 months at -20°C.
Packaging Information
Material Size 5 mg
Transport Information
Supplemental Information
Specifications

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