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Anti-SEL1L (rabbit polyclonal)

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货号：ABS654

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H, Ca, R WB, IP Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS54
Description Anti-AS160 Antibody
Alternate Names
  • Acrg embryonic lethality minimal region ortholog
  • Akt substrate of 160 kDa
  • TBC (Tre-2, BUB2, CDC16) domain-containing protein
  • TBC1 domain family, member
Background Information AS160 (Akt Substrate of 160 kDa, Akt1S1), Rab GAP (GTPase activating protein), is phosphorylated on multiple sites by Akt in response to insulin in adipocytes and contraction in muscles. AS160 is the long sought after link between the upstream insulin signaling through insulin/PI3K/Akt and GLUT4 vessicle translocation to the cell membrane. It has 6 Akt phosphorylation consensus sequences that are believed to become phosphorylated upon insulin stimulation. This phosphorylation is required for translocation of GLUT4-containing vesicles to the cell membrane1. A mutation of two or more of these phosphorylation sites results in a dramatic decrease in AS160 activity and insulin-stimulated GLUT4 redistribution at the cell membrane2. AS160 has also shown to be important for GLUT4 expcytosis2.
References
Product Information
Format Affinity Purified
Control
  • HEPG2 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Anti-AS160 Antibody detects level of AS160 & has been published & validated for use in WB & IP.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Application Notes Western Blot (SNAP ID) Analysis: 1 µg/mL from a previous lot detected AS160 on 10 µg of HEPG2 cell lysate.

Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated AS160 from HEPG2 lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of mouse AS160.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes AS160 at the C-terminus.
Species Reactivity
  • Mouse
  • Human
  • Canine
  • Rat
Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react on canine and rat based on 100% sequence homology.
Chimpanzee, equine, and ox (90% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • AS160
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity).

SUBCELLULAR LOCATION: Cytoplasm. Note: Cytoplasmic perinuclear (by similarity).

TISSUE SPECIFICTY: Widely expressed, including in pancreatic beta cells.

PTM: Phosphorylated by AKT1; insulin-induced.

Insulin-stimulated phosphorylation is required for GLUT4 translocation. Has no effect on GLUT4 internalization.

SEQUENCE SIMILARITIES: Contains 2 PID domains.

Contains 1 Rab-GAP TBC domain.
Molecular Weight ~ 160 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HEPG2 cell lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected AS160 on 10 µg of HEPG2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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